Iron in Energy and Pharmaceutical Chemistry: A Review
Abstract
Iron, a versatile and abundant element, plays a pivotal role in various fields, particularly in energy and pharmaceutical chemistry. This review highlights the significance of iron-based compounds and materials in renewable energy applications, including catalysis and energy storage, as well as their crucial roles in pharmaceutical development and drug design. The discussion encompasses recent advancements in iron catalysis for chemical reactions essential to energy production, the development of iron-based energy storage systems like batteries and redox flow cells, and the exploration of iron compounds in photocatalysis and solar energy conversion. Additionally, it delves into the therapeutic applications of iron in antimalarial drugs, cancer treatments, and diagnostic imaging, as well as the use of iron chelators for managing iron overload disorders. The review also addresses the challenges related to catalyst stability, efficiency, and biocompatibility of ironbased compounds. Finally, it outlines future prospects, emphasizing the potential of nanoengineering and hybrid systems to further enhance the performance and applicability of iron in these critical fields.
References
Chemistry. 2022 Apr 7;3(2):149-71.
2. Fischer FA, Tropsch H. The synthesis of petroleum at atmospheric pressures from gasification products of
coal. Brennstoff-Chemie. 1926;7(7):97-104.
3. Armor JN. The multiple roles for catalysis in the production of H2. Applied Catalysis A: General. 1999 Jan 25;176(2):159-76.
4. Yang Z, Zhang J, Kintner-Meyer MC, Lu X, Choi D, Lemmon JP, Liu J. Electrochemical energy storage for
green grid. Chemical reviews. 2011 May 11;111(5):3577-613.
5. Hocking RK, Wasinger EC, Yan YL, Degroot FM, Walker FA, Hodgson KO, Hedman B, Solomon EI. Fe L-edge
X-ray absorption spectroscopy of low-spin heme relative to non-heme Fe complexes: Delocalization of
Fe d-electrons into the porphyrin ligand. Journal of the American Chemical Society. 2007 Jan 10;129(1):113-25.
6. Wang D, Zhao Y. Single-atom engineering of metalorganic frameworks toward healthcare. Chem. 2021
Oct 14;7(10):2635-71.
7. Crabtree GW, Lewis NS. Solar energy conversion. Physics today. 2007 Mar 1;60(3):37-42.
8. McQuade DT, Pullen AE, Swager TM. Conjugated polymer-based chemical sensors. Chemical reviews.
2000 Jul 12;100(7):2537-74.
9. Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism.
cell. 2004 Apr 30;117(3):285-97.
10. Arami H, Khandhar A, Liggitt D, Krishnan KM. In vivo delivery, pharmacokinetics, biodistribution and toxicity
of iron oxide nanoparticles. Chemical Society Reviews. 2015;44(23):8576-607