Bioreactors and Bioprocesses: Advancements in Biochemical Engineering

  • Shivani Malik Student, Department of Chemical & Petro Chemicals, Satyabama Institute of Science And Technology Business Incubator, Chennai, Tamil Nadu.

Abstract

Bioreactors and bioprocesses are integral to the field of biochemical engineering, facilitating the production of a wide array of valuable bioproducts. This comprehensive review article explores the latest developments in bioreactor design, operation, and bioprocess optimization, providing insights into the key challenges, emerging technologies, and their transformative impact across various industries. From novel bioreactor designs and scalability considerations to advanced monitoring and control systems, the evolving landscape of bioprocessing is analyzed. Moreover, this article sheds light on how bioreactors are contributing to sustainable production practices, reducing the environmental footprint of numerous sectors. The review concludes by underscoring the significance of continued innovation and collaboration to fully harness the potential of bioreactors in shaping the future of biochemical engineering.

References

1. Lee S Y, Kim H U, Chae T U. Industrial biotechnology: Perspectives and future prospects. In Industrial Biotechnology 2015; (pp. 1-23). Springer.
2. Pandey A, Soccol C R, Larroche C. Current developments in solid-state fermentation. Biochemical Engineering
Journal, 2008; 44(1): 13-18.
3. Nielsen J, Villadsen J. Bioreaction engineering principles. Springer Science & Business Media 2013.
4. Ozturk S S. Biopharmaceutical manufacturing: history and future. In Biopharmaceutical Production Technology
2015; (pp. 1-9). John Wiley & Sons.
5. Shuler M L, Kargi F. Bioprocess engineering: basic concepts. Pearson Education India 2002.
6. Gernaey K V, Woodley J M. Model-based design of monitoring and control strategies in the biopharmaceutical industry. Computers & Chemical Engineering, 2006; 30(10-12): 1436-1447.
7. Schmid A, Dordick J S, Hauer B, et al. Industrial biocatalysis today and tomorrow. Nature, 2001; 409(6817): 258-268.
8. Gomes N, Marta A A, Oliveira P. Bioreactors for lignocellulose-to-ethanol conversion: processes development and optimization. Bioprocess and Biosystems Engineering, 2017; 40(4): 487-511.
9. Villadsen J, Michelsen M L. Solution of differential equation models by polynomial approximation. Springer Science & Business Media 2013.
10. Kompala D S, Ramkrishna D, Tsao G T. A generalized stoichiometry of growth and product formation.
Biotechnology and Bioengineering, 1987; 29(1): 91-103.
11. Zhang Y, Schmid A. Bioreactors for high cell density and continuous multi-stage bio-catalytic processes: Recent advances. Current Opinion in Chemical Engineering, 2020; 27, 85-93.
12. Carvalho A L, Cardoso J, Gil M H. et al. Bioreactor design for protein production. In Biofuels, Bioproducts and
Biorefining 2015; (Vol. 9, No. 5, pp. 621-635). John Wiley & Sons.
13. Roels J A. Benchmarking of industrial reactor performance by searching for the Pareto frontier of reactor performance. Chemical Engineering Science, 2013; 98, 255-264.
14. Blanch H W, Clark D S. Biochemical engineering. CRC press 1997.
15. Kantardjieff A, Houston J E. Protein storage and stability in human spaceflight. Journal of Pharmaceutical
Sciences, 2002; 91(7): 1725-1741.
16. González García R A, McCubbin T, Enhancing bioprocess efficiency through implementation of quality by design principles. Trends in Biotechnology, 2016; 34(12): 926- 938.
17. Blanch H W, Clark D S. Biochemical engineering. CRC press 1997.
18. Xiao W. Advances in yeast protein expression systems. FEMS Yeast Research, 2010; 10(8): 823-830.
Published
2024-02-12
How to Cite
MALIK, Shivani. Bioreactors and Bioprocesses: Advancements in Biochemical Engineering. Journal of Advanced Research in Applied Chemistry and Chemical Engineering, [S.l.], v. 6, n. 2, p. 1-7, feb. 2024. Available at: <http://thejournalshouse.com/index.php/Journal-Chemistry-ChemEng/article/view/954>. Date accessed: 19 apr. 2025.